Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294083 | 0.84 | NOS3 (0.31) | — | |
| SCHEMBL13984187 | 0.83 | USP28 (0.33) | DPP4 | |
| SCHEMBL6510330 | 0.81 | GRIN2D (0.36) | ESR1ESR2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL15132117 | 0.81 | GRIN2D (0.42) | DPP4GPR84ESR1ESR2GRIN2D | |
| SCHEMBL12961324 | 0.79 | MCL1 (0.34) | — | |
| SCHEMBL22609683 | 0.78 | TRPV4 (0.41) | — | |
| SCHEMBL12931066 | 0.78 | GABRP (0.39) | — | |
| SCHEMBL6817121 | 0.76 | DPP4 (0.46) | DPP4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL19489957 | 0.75 | DPP4 (0.39) | DPP4ESR1ESR2GRIN2DGRIN3B | |
| SCHEMBL25354840 | 0.75 | TP53 (0.32) | GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-B1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |