Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.52 |
| ▸ | HRH1 | P35367 | 7/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877772 | 0.84 | TSHR (0.71) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16363659 | 0.79 | TSHR (0.64) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15478270 | 0.79 | TSHR (0.82) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| Talastine SCHEMBL30502 | 0.78 | ADRA1A (0.81) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| Talastine SCHEMBL29350005 | 0.78 | ADRA1A (0.81) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8556390 | 0.77 | ENPP1 (0.65) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12862543 | 0.77 | LMNA (0.59) | TSHRL3MBTL1SMN1; SMN2HSD17B10TDP1 | |
| SCHEMBL12892041 | 0.77 | TSHR (0.78) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| Talastine SCHEMBL1650995 | 0.76 | ADRA1A (0.78) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11985477 | 0.76 | TSHR (0.76) | TSHRL3MBTL1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501786-B2 | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-08-06 | — | — | US | disclosed |
| US-20110028461-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028461-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | TSHR 346/4885L3MBTL1 4252/4885CYP1A2 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.