Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.48 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.48 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16079047 | 0.94 | TRPC5 (0.54) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL16079049 | 0.83 | TRPC5 (0.60) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL16028322 | 0.82 | P2RX3 (0.52) | TRPC4TRPC5TRPC1P2RX3LMNA | |
| SCHEMBL19375485 | 0.82 | P2RX3 (0.48) | TRPC4TRPC5TRPC1P2RX3LMNA | |
| SCHEMBL16028314 | 0.82 | TRPC5 (0.53) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL16079032 | 0.82 | TRPC5 (0.59) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL16079039 | 0.81 | TRPC5 (0.56) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL16028596 | 0.81 | TRPC5 (0.54) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL18834889 | 0.81 | TRPC5 (0.54) | TRPC4TRPC5TRPC1P2RX3KCNH2 | |
| SCHEMBL18833876 | 0.80 | P2RX3 (0.53) | TRPC4TRPC5P2RX3KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014143799-A9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-12-24 | — | — | WO | disclosed |