Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.39 |
| ▸ | PDE5A | O76074 | 11/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16370484 | 0.91 | DGAT1 (0.39) | DGAT1PDE5ANPC1 | |
| SCHEMBL18671464 | 0.89 | PDE5A (0.32) | PDE5A | |
| SCHEMBL16370405 | 0.86 | DGAT1 (0.33) | DGAT1PDE5A | |
| SCHEMBL18671467 | 0.80 | PDE5A (0.33) | PDE5A | |
| SCHEMBL16370287 | 0.78 | PDE5A (0.55) | PDE5A | |
| SCHEMBL17766175 | 0.76 | PDE5A (0.38) | DGAT1PDE5A | |
| SCHEMBL16370265 | 0.71 | PDE5A (0.63) | PDE5A | |
| SCHEMBL16370351 | 0.71 | PDE5A (0.62) | PDE5A | |
| SCHEMBL16370332 | 0.70 | PDE5A (0.38) | DGAT1PDE5A | |
| SCHEMBL15120877 | 0.69 | PDE5A (0.57) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9605008-B2 | Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-03-28 | — | — | US | disclosed |
| US-9605008-B2 | Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-03-28 | — | — | US | disclosed |
| US-9605008-B2 | Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-03-28 | — | — | US | disclosed |
| US-20160145271-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20160145271-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20160145271-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-26 | — | — | US | disclosed |
| EP-3019506-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015004105-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145271-A1 | BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF | PNPO, PLPBP, CYP4B1 | DGAT1 4591/4885PDE5A 439/4885NPC1 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.