Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17799641 | 1.00 | GRM5 (0.51) | GRM5SSTR4DHODHRAB9ATRPV1 | |
| SCHEMBL17799744 | 0.88 | TLR7 (0.40) | GRM5SSTR4AKT1PDE4APDE4B | |
| SCHEMBL17799721 | 0.86 | HCRTR1 (0.47) | AKT1TLR7FPR1FPR2HCRTR1 | |
| SCHEMBL17799665 | 0.85 | AKT1 (0.40) | AKT1FPR1FPR2 | |
| SCHEMBL16371914 | 0.85 | AKT1 (0.40) | AKT1FPR1FPR2 | |
| SCHEMBL17799629 | 0.85 | HCRTR1 (0.52) | SSTR4AKT1FPR1HCRTR1 | |
| SCHEMBL17799639 | 0.84 | GRM5 (0.55) | GRM5DHODHRAB9APDE4APDE4B | |
| SCHEMBL16372105 | 0.84 | GRM5 (0.55) | GRM5DHODHRAB9APDE4APDE4B | |
| SCHEMBL17799694 | 0.83 | P2RX7 (0.47) | SSTR4RAB9AAKT1TAS1R3TAS1R1 | |
| SCHEMBL16371875 | 0.83 | P2RX7 (0.47) | SSTR4RAB9AAKT1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019476-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | Syngenta Participations AG (CH) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003951-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-15 | — | — | WO | disclosed |