SCHEMBL17799629

SCHEMBL17799629

COc1cccnc1C(=O)N[C@H]1CC[C@H]1c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ HCRTR1 O43613 12/20 0.52
▸ FPR1 P21462 1/20 0.41
▸ AKT1 P31749 2/20 0.39
▸ SSTR4 P31391 2/20 0.39
▸ EPHX2 P34913 1/20 0.39
▸ CTSA P10619 1/20 0.39
▸ HCRTR2 O43614 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799688 0.85 HCRTR1 (0.48) HCRTR1EPHX2HCRTR2
SCHEMBL17799641 0.85 GRM5 (0.51) HCRTR1FPR1AKT1SSTR4
SCHEMBL16372224 0.85 GRM5 (0.51) HCRTR1FPR1AKT1SSTR4
SCHEMBL17799744 0.85 TLR7 (0.40) HCRTR1FPR1AKT1SSTR4
SCHEMBL17799721 0.83 HCRTR1 (0.47) HCRTR1FPR1AKT1
SCHEMBL17799750 0.81 LMNA (0.54) —
SCHEMBL17799665 0.80 AKT1 (0.40) FPR1AKT1
SCHEMBL16371914 0.80 AKT1 (0.40) FPR1AKT1
SCHEMBL17799719 0.80 GRM5 (0.45) FPR1AKT1SSTR4
SCHEMBL18636344 0.79 HCRTR1 (0.67) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS HCRTR1 57/4885FPR1 605/4885AKT1 4061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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