Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17799749 | 1.00 | SIGMAR1 (0.45) | SIGMAR1SLC6A12TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL17799743 | 0.89 | SLC6A12 (0.47) | SLC6A12TAS1R3TAS1R1TAS1R2NPC1 | |
| SCHEMBL17799642 | 0.86 | GRM5 (0.52) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL17799710 | 0.86 | NPC1 (0.47) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL16372221 | 0.86 | GRM5 (0.52) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL17799736 | 0.86 | TAS1R3 (0.49) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL16451640 | 0.83 | HCRTR1 (0.45) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL15295032 | 0.83 | HCRTR1 (0.45) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL15295033 | 0.83 | HCRTR1 (0.45) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL17799690 | 0.83 | PPIA (0.41) | SLC6A12TAS1R3TAS1R1TAS1R2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019476-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | Syngenta Participations AG (CH) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003951-A1 | 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-15 | — | — | WO | disclosed |