SCHEMBL17799736

SCHEMBL17799736

Cc1ccccc1C(=O)N[C@H]1CC[C@H]1c1ccc(Cl)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAS1R3 Q7RTX0 4/20 0.49
▸ TAS1R1 Q7RTX1 4/20 0.49
▸ TAS1R2 Q8TE23 4/20 0.49
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ HTT P42858 1/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ KCNMA1 Q12791 1/20 0.46
▸ POLB P06746 2/20 0.45
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ GAA P10253 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ F10 P00742 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ GLA P06280 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799743 0.89 SLC6A12 (0.47) TAS1R3TAS1R1TAS1R2NPC1RAB9A
SCHEMBL16372239 0.86 SIGMAR1 (0.45) TAS1R3TAS1R1TAS1R2NPC1RAB9A
SCHEMBL17799642 0.86 GRM5 (0.52) TAS1R3TAS1R1TAS1R2RAB9AKDM4E
SCHEMBL17799710 0.86 NPC1 (0.47) TAS1R3TAS1R1TAS1R2NPC1RAB9A
SCHEMBL17799749 0.86 SIGMAR1 (0.45) TAS1R3TAS1R1TAS1R2NPC1RAB9A
SCHEMBL16372221 0.86 GRM5 (0.52) TAS1R3TAS1R1TAS1R2RAB9AKDM4E
SCHEMBL17799745 0.85 KDM4E (0.49) NPC1RAB9AKDM4EKCNMA1MEN1
SCHEMBL16372250 0.84 P2RX7 (0.43) TAS1R3TAS1R1TAS1R2GAAALDH1A1
SCHEMBL17799715 0.84 P2RX7 (0.43) TAS1R3TAS1R1TAS1R2GAAALDH1A1
SCHEMBL17799662 0.84 TAS1R3 (0.43) TAS1R3TAS1R1TAS1R2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS TAS1R3 3195/4885TAS1R1 3418/4885TAS1R2 2989/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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