Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821168 | 1.00 | MAPT (0.49) | MAPTL3MBTL1AKR1C3MMP2MMP3 | |
| SCHEMBL7053252 | 0.90 | IGF1R (0.45) | MAPTL3MBTL1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7734103 | 0.89 | MAPT (0.46) | MAPTL3MBTL1ALDH1A1RAB9AKMT2A | |
| SCHEMBL1819239 | 0.84 | MAPT (0.41) | MAPTL3MBTL1MMP2MMP3MMP13 | |
| SCHEMBL4649497 | 0.83 | KDM4E (0.46) | MAPTAKR1C3ALDH1A1KMT2AIGF1R | |
| SCHEMBL8358624 | 0.83 | GRM5 (0.51) | MAPTL3MBTL1AKR1C3ALDH1A1RAB9A | |
| SCHEMBL4649145 | 0.83 | LMNA (0.49) | MAPTL3MBTL1AKR1C3ALDH1A1RAB9A | |
| SCHEMBL27165415 | 0.82 | HIF1A (0.47) | MAPTALDH1A1KMT2APRKDCKDM4E | |
| SCHEMBL1820200 | 0.82 | ACACB (0.38) | MAPTMMP2MMP3MMP13ALDH1A1 | |
| SCHEMBL9942722 | 0.82 | APP (0.53) | L3MBTL1ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030518-A1 | PHOTOCHROMIC MATERIALS HAVING EXTENDED PI-CONJUGATED SYSTEMS AND COMPOSITIONS AND ARTICLES INCLUDING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| EP-1214311-A1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019813-A1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |