Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 6/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 6/20 | 0.33 |
| ▸ | UGCG | Q16739 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783259 | 0.94 | KMT2A (0.36) | MEN1KMT2APKMPIK3CDPIK3R2 | |
| SCHEMBL16377940 | 0.93 | MEN1 (0.35) | MEN1KMT2APKMPIK3CDPIK3R2 | |
| SCHEMBL16377690 | 0.88 | PIK3CD (0.33) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL16377700 | 0.83 | CCNA2 (0.37) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL16377835 | 0.81 | MTNR1A (0.34) | KMT2AALDH1A1CYP3A4POLB | |
| SCHEMBL16377693 | 0.81 | PIK3CD (0.35) | MEN1KMT2APIK3CDPIK3R2PIK3CA | |
| SCHEMBL16377793 | 0.81 | PIK3CD (0.33) | MEN1KMT2APIK3CDPIK3R2PIK3CA | |
| SCHEMBL16377953 | 0.81 | ALDH1A1 (0.34) | MEN1KMT2APKMPIK3CDPIK3R2 | |
| SCHEMBL20579991 | 0.81 | UGCG (0.34) | MEN1KMT2APIK3CDPIK3R2PIK3CA | |
| SCHEMBL16377694 | 0.81 | UGCG (0.34) | MEN1KMT2APIK3CDPIK3R2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2022-06-21 | — | — | US | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| WO-2014209980-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | FSHR, GNRHR, LHCGR | MEN1 2298/4885KMT2A 2435/4885PKM 1140/4885 |
| US-20160152626-A1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | FSHR, GNRHR, LHCGR | MEN1 2298/4885KMT2A 2435/4885PKM 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.