Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060129 | 1.00 | KMT2A (0.54) | KMT2AGFERHRH3TSHRMAPT | |
| SCHEMBL8053460 | 0.95 | GFER (0.53) | KMT2AGFERHRH3TSHRMAPT | |
| SCHEMBL24522282 | 0.81 | PDK2 (0.44) | KMT2AGFERHRH3LMNASMN1; SMN2 | |
| SCHEMBL27865371 | 0.81 | OPRM1 (0.49) | PDK2 | |
| SCHEMBL12802636 | 0.81 | ADRA2C (0.49) | KMT2AGFERMAPTPDK2 | |
| SCHEMBL12802638 | 0.81 | ADRA2C (0.49) | KMT2AGFERMAPTPDK2 | |
| SCHEMBL25732648 | 0.81 | KMT2A (0.52) | KMT2AGFERTSHRMAPTNPSR1 | |
| SCHEMBL15160573 | 0.80 | HRH3 (0.55) | KMT2AGFERHRH3TSHRMAPT | |
| SCHEMBL3535701 | 0.80 | MAOA (0.54) | KMT2ATSHRMAPTLMNASMN1; SMN2 | |
| SCHEMBL8284787 | 0.80 | MAOA (0.54) | KMT2ATSHRMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921383-B2 | Thiazolopyrimidine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-12-30 | — | — | US | disclosed |