Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 6/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060129 | 0.81 | KMT2A (0.54) | PDK2KMT2AGFERHRH3LMNA | |
| SCHEMBL16378121 | 0.81 | KMT2A (0.54) | PDK2KMT2AGFERHRH3LMNA | |
| SCHEMBL27865371 | 0.80 | OPRM1 (0.49) | PDK2PBRM1SMARCA2SMARCA4NR1I2 | |
| SCHEMBL12802636 | 0.80 | ADRA2C (0.49) | PDK2ARKMT2APBRM1SMARCA2 | |
| SCHEMBL12802638 | 0.80 | ADRA2C (0.49) | PDK2ARKMT2APBRM1SMARCA2 | |
| SCHEMBL15160573 | 0.79 | HRH3 (0.55) | KMT2AGFERHRH3HTTSMN1; SMN2 | |
| SCHEMBL8284787 | 0.78 | MAOA (0.54) | PDK2ARMAOAMAOBKMT2A | |
| SCHEMBL3535701 | 0.78 | MAOA (0.54) | PDK2ARMAOAMAOBKMT2A | |
| SCHEMBL17083432 | 0.78 | PDK2 (0.45) | PDK2ARMAOAMAOBKMT2A | |
| SCHEMBL12160691 | 0.78 | NOTUM (0.47) | PDK2ARMAOAMAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4015504-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |