Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.41 |
| ▸ | MMP1 | P03956 | 5/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18744701 | 0.94 | MMP13 (0.42) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL19156547 | 0.94 | MMP13 (0.43) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL23953171 | 0.87 | MMP13 (0.42) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL23953155 | 0.81 | RORC (0.44) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL12508301 | 0.80 | ALOX5AP (0.46) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL19156975 | 0.79 | MMP1 (0.46) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL18744703 | 0.78 | TDO2 (0.43) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL19156814 | 0.77 | TDO2 (0.41) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL23953158 | 0.77 | CA12 (0.43) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL19681317 | 0.76 | ALOX5AP (0.46) | MMP13MMP1MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014207445-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)BENZENESULFONAMIDES AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2014-12-31 | — | — | WO | disclosed |