Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192097 | 0.79 | ESR1 (0.61) | ALDH1A1HPGDHSD17B10ALOX15MEN1 | |
| SCHEMBL3281904 | 0.79 | NPC1 (0.38) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL930516 | 0.77 | SHBG (0.57) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL21268187 | 0.76 | KIF11 (0.43) | ALDH1A1TSHRESR1ESR2 | |
| SCHEMBL227931 | 0.73 | TSHR (0.40) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL1550638 | 0.73 | TSHR (0.46) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL930517 | 0.72 | CNR2 (0.47) | — | |
| SCHEMBL25227526 | 0.71 | POLB (0.39) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL6225432 | 0.71 | TSHR (0.39) | LMNATYRALDH1A1HPGDHSD17B10 | |
| SCHEMBL17262489 | 0.71 | TSHR (0.39) | LMNATYRALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | claimed |
| EP-2194975-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS | Acumen Pharmaceuticals, Inc. (US) | 2010-06-16 | — | — | EP | claimed |
| WO-2009009768-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | claimed |
| US-6884815-B1 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2005-04-26 | — | — | US | claimed |
| US-6783913-B2 | POLYMERIC ACETAL RESIN CONTAINS UNITS (A), (B), (C), (D), AND (E). UNIT (A) IS A VINYL ALCOHOL UNIT. UNIT; (B) IS A POLYVINYL ACETAL UNIT CONTAINING AN R GROUP, WHERE R IS HYDROGEN, AN ALIPHATIC GROUP, AN AROMATIC GROUP, OR AN | KODAK POLYCHROME GRAPHICS LLC | 2004-08-31 | — | — | US | claimed |
| US-20030198887-A1 | Polymeric acetal resins containing free radical inhibitors and their use in lithographic printing | EASTMAN KODAK COMPANY | 2003-10-23 | — | — | US | claimed |
| US-6436961-B1 | SUBSTANCE P RECEPTOR ANTAGONIST; 2-PHENYL-3-BENZYLAMINOPIPERIDINES | PFIZER INC | 2002-08-20 | — | — | US | claimed |
| US-6174941-B1 | FOR STABILIZING CHLORINE CONTAINING POLYMERS SUCH AS POLYVINYL CHLORIDE | WITCO VINYL ADDITIVES GMBH (DE) | 2001-01-16 | — | — | US | claimed |
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | claimed |
| US-9981910-B2 | Substituted pyrrolidines and methods of use | ABBVIE S.Á.R.L. (LU) | 2018-05-29 | — | — | US | disclosed |
| EP-1910454-B2 | TRIETHANOLAMINE PERCHLORATO (TRIFLATO) METAL INNER COMPLEX COORDINATION POLYMERS AS ADDITIVES FOR SYNTHETIC POLYMERS | CATENA ADDITIVES GMBH & CO KG (DE) | 2016-11-30 | — | — | EP | disclosed |
| CN-101248128-B | Coordination polymeric triethanolamine perchloric acid (triflato) metal inner complexes as additives for synthetic polymers | CATENA ADDITIVES GMBH & CO KG | 2012-05-09 | — | — | CN | disclosed |
| CN-102136506-A | Sealing film for solar battery module and manufacturing method thereof | KASEI CO C I | 2011-07-27 | — | — | CN | disclosed |
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| US-5173496-A | Antiinflammatory agents | ICI PHARMA (FR) | 1992-12-22 | — | — | US | disclosed |
| CN-1046529-A | Carbostyril derivative | OTSUKA PHARMA CO LTD (JP) | 1990-10-31 | — | — | CN | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| US-4379876-A | Methyl methacrylate-butadiene-styrene impact modifier polymers, polyvinyl chloride, compositions and methods | ROHM AND HAAS COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| US-4321191-A | THIO-CONTAINING POLYESTERS, POLYCARBONATES, AND COMPOUNDS; HEAT RESISTANCE; DISCOLORATION INHIBITION; MECHANICAL PROPERTIES | ARGUS CHEMICAL CORP. (US) | 1982-03-23 | — | — | US | disclosed |
| US-3968102-A | VASODILATOR, ANTICOAGULANT | KOHJIN CO., LTD. (JA) | 1976-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | LMNA 2595/4885TYR 3710/4885ALDH1A1 592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.