Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 9/20 | 0.50 |
| ▸ | CA2 | P00918 | 9/20 | 0.50 |
| ▸ | CA9 | Q16790 | 9/20 | 0.50 |
| ▸ | CA12 | O43570 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13903999 | 0.87 | CA12 (0.61) | LMNACA1CA2CA9CA12 | |
| SCHEMBL21133688 | 0.87 | LMNA (0.50) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL11515374 | 0.86 | LMNA (0.48) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL11515380 | 0.86 | LMNA (0.48) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL22559700 | 0.85 | LMNA (0.55) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL16392573 | 0.84 | CA1 (0.49) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL9524271 | 0.84 | CA1 (0.49) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL16392618 | 0.84 | LMNA (0.50) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL9735191 | 0.84 | CA1 (0.49) | LMNAKMT2ACA1CA2CA9 | |
| SCHEMBL6950432 | 0.82 | LMNA (0.67) | LMNAKMT2ACA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015006740-A2 | OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-01-15 | — | — | WO | disclosed |