SCHEMBL1639619

SCHEMBL1639619

Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8942951 0.94 TSHR (0.33) SMN1; SMN2TSHR
SCHEMBL7868555 0.91 SMN1; SMN2 (0.34) SMN1; SMN2TSHRMEN1KMT2A
SCHEMBL24227302 0.88 TSHR (0.33) SMN1; SMN2TSHR
SCHEMBL7869945 0.88
SCHEMBL7872028 0.88 TSHR (0.31) SMN1; SMN2TSHR
SCHEMBL7868542 0.85
SCHEMBL8942917 0.85 TSHR (0.30) SMN1; SMN2TSHR
SCHEMBL24227301 0.85 SMN1; SMN2 (0.34) SMN1; SMN2TSHRMEN1KMT2A
SCHEMBL7872076 0.84
SCHEMBL312355 0.83 SMN1; SMN2 (0.42) SMN1; SMN2TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431706-A Fatigue-resistant polyurethane elastomer and preparation method and application thereof 万勋科技(深圳)有限公司 2025-02-14 CN claimed
CN-111172618-A Industrial alkali-resistant brush wire and preparation method thereof 安徽诚德刷业有限公司 2020-05-19 CN claimed
CN-101385185-B Rechargeable lithium-ion cell with triphenylamine redox shuttle 3M INNOVATIVE PROPERTIES CO 2011-05-04 CN claimed
CN-101385185-A Rechargeable lithium-ion cell with triphenylamine redox shuttle 3M INNOVATIVE PROPERTIES CO (US) 2009-03-11 CN claimed
US-6653353-B2 Hair styling anionic polymer and fluoroamines mixture improves the holding power of styling resins under high humidity conditions UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-11-25 US claimed
US-20020176834-A1 Cosmetic and personal care compositions UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2002-11-28 US claimed
US-20250361249-A1 SURFACE TREATMENT AGENT DAIKIN INDUSTRIES, LTD. (JP) 2025-11-27 US disclosed
EP-4644398-A1 SURFACE TREATMENT AGENT Daikin Industries, Ltd. (JP) 2025-11-05 EP disclosed
US-20250205232-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-06-26 US disclosed
CN-119431706-A Fatigue-resistant polyurethane elastomer and preparation method and application thereof 万勋科技(深圳)有限公司 2025-02-14 CN disclosed
US-12168009-B2 Modulators of cystic fibrosis transmembrane conductance regulator VERTEX PHARMACEUTICALS INCORPORATED (US) 2024-12-17 US disclosed
WO-2024172036-A1 SURFACE TREATMENT AGENT ダイキン工業株式会社 2024-08-22 WO disclosed
WO-2024061807-A1 ORGANIC ELECTRONIC DEVICE COMPRISING A CHARGE GENERATION LAYER NOVALED GMBH (DE) 2024-03-28 WO disclosed
CN-1362972-A Olefin polymer and process for producing the same MITSUI CHEMICALS INC (JP) 2002-08-07 CN disclosed
EP-1197500-A1 OLEFIN POLYMERS AND PRODUCTION PROCESSES THEREOF Mitsui Chemicals, Inc. (JP) 2002-04-17 EP disclosed
EP-0710257-A1 IMIDO TRANSITION METAL COMPLEX METATHESIS CATALYSTS SHELL OIL CO (US) 1996-05-08 EP disclosed
WO-1995003346-A1 IMIDO TRANSITION METAL COMPLEX METATHESIS CATALYSTS SHELL OIL COMPANY (US) 1995-02-02 WO disclosed
EP-0318796-B1 SUBSTITUTED BENZOYL(THIO) UREAS BAYER AG (DE) 1993-06-16 EP disclosed
US-5096928-A Caterpillars BAYER AKTIENGESELLSCHAFT (DE) 1992-03-17 US disclosed
EP-0318796-A2 Substituted benzoyl(thio) ureas BAYER AG (DE) 1989-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250205232-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1B, SLC26A4 SMN1; SMN2 4751/4885TSHR 1187/4885MEN1 4405/4885
US-12168009-B2 Modulators of cystic fibrosis transmembrane conductance regulator CFTR, SCNN1B, SLC26A4 SMN1; SMN2 4751/4885TSHR 1187/4885MEN1 4405/4885
US-20250361249-A1 SURFACE TREATMENT AGENT ITGA1, ITGB1, GDI1 SMN1; SMN2 1755/4885TSHR 395/4885MEN1 534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.