SCHEMBL163993

SCHEMBL163993

NC(=O)NCc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 1.00
MAPT P10636 1/20 0.64
ALDH1A1 P00352 2/20 0.64
FES P07332 1/20 0.62
RET P07949 1/20 0.62
MARK3 P27448 1/20 0.62
TYK2 P29597 1/20 0.62
FLT4 P35916 1/20 0.62
SYK P43405 1/20 0.62
CLK2 P49760 1/20 0.62
CLK4 Q9HAZ1 1/20 0.62
GAA P10253 2/20 0.61
CYP3A4 P08684 2/20 0.60
USP2 O75604 2/20 0.60
CYP1A2 P05177 2/20 0.60
NPSR1 Q6W5P4 1/20 0.60
CYP2C9 P11712 1/20 0.60
CYP2C19 P33261 1/20 0.60
PKM P14618 1/20 0.60
KMT2A Q03164 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29550751 1.00 RECQL (1.00) RECQLMAPTALDH1A1FESRET
SCHEMBL30559826 0.87 RECQL (0.77) RECQLMAPTALDH1A1FESRET
SCHEMBL25779421 0.86 RECQL (0.76) RECQLMAPTALDH1A1FESRET
SCHEMBL1704281 0.86 RECQL (0.75) RECQLMAPTALDH1A1FESRET
SCHEMBL29460250 0.85 FES (0.81) RECQLMAPTALDH1A1FESRET
SCHEMBL9130703 0.85 FES (0.81) RECQLMAPTALDH1A1FESRET
SCHEMBL2424556 0.84 RECQL (0.72) RECQLMAPTALDH1A1FESRET
SCHEMBL10403403 0.84 RECQL (0.72) RECQLMAPTALDH1A1FESRET
SCHEMBL27823198 0.83 RECQL (0.70) RECQLSMN1; SMN2L3MBTL1LMNA
SCHEMBL1274303 0.83 RECQL (0.71) RECQLMAPTALDH1A1FESRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 452 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114656402-B Fluorine-containing nicotinoyl urea compound and application thereof 青岛科技大学 2024-01-30 CN claimed
WO-2023156070-A1 COSMETIC COMPOSITION THE BOOTS COMPANY PLC (GB) 2023-08-24 WO claimed
CN-114656402-A Fluorine-containing nicotinoyl urea compound and application thereof 青岛科技大学 2022-06-24 CN claimed
US-11279687-B2 Compounds and compositions for the inhibition of NAMPT VALO HEALTH, INC. (US) 2022-03-22 US claimed
CN-108697081-B Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 美国陶氏益农公司 2021-07-23 CN claimed
EP-3638669-A1 SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES Bayer Pharma Aktiengesellschaft (DE) 2020-04-22 EP claimed
CN-109836415-A Carbamide compounds as ALK inhibitor 北京博远精准医疗科技有限公司 2019-06-04 CN claimed
WO-2018228920-A1 SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-12-20 WO claimed
WO-2016209785-A1 UREA GELLANTS THE PROCTER & GAMBLE COMPANY (US) 2016-12-29 WO claimed
US-20160369208-A1 UREA GELLANT THE PROCTER & GAMBLE COMPANY 2016-12-22 US claimed
CN-1494410-A Anhydrous antiperspirant and deodorant compositions containing solid, water-soluble, skin active agent 2004-05-05 CN claimed
EP-1367985-A2 ANHYDROUS ANTIPERSPIRANT AND DEODORANT COMPOSITIONS CONTAINING A SOLID, WATER-SOLUBLE, SKIN ACTIVE AGENT THE PROCTER & GAMBLE COMPANY (US) 2003-12-10 EP claimed
EP-0896522-B1 METHODS OF REGULATING SKIN APPEARANCE WITH VITAMIN B 3 COMPOUND PROCTER & GAMBLE (US) 2003-10-22 EP claimed
WO-2002069916-A2 ANHYDROUS ANTIPERSPIRANT AND DEODORANT COMPOSITIONS CONTAINING A SOLID, WATER-SOLUBLE, SKIN ACTIVE AGENT THE PROCTER & GAMBLE COMPANY (US) 2002-09-12 WO claimed
US-6383476-B1 Anhydrous antiperspirant and deodorant compositions containing a solid, water-soluble, skin active agent THE PROCTER & GAMBLE COMPANY 2002-05-07 US claimed
CN-1251523-A Sulfonamide derivatives LILLY CO ELI (US) 2000-04-26 CN claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
WO-1998033786-A9 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS 1998-12-30 WO claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed
US-5096978-A Butadiene polymers having improved scorch delay and fast cure rates; tires; treads MONSANTO COMPANY (US) 1992-03-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11279687-B2 Compounds and compositions for the inhibition of NAMPT NAMPT, NNT, NQO1 RECQL 2720/4885MAPT 694/4885ALDH1A1 511/4885
US-20160369208-A1 UREA GELLANT UGP2, UGGT1, SLC14A1 RECQL 1897/4885MAPT 160/4885ALDH1A1 1672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.