Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14157206 | 0.79 | GRM5 (0.33) | GRM5 | |
| SCHEMBL14157270 | 0.72 | LMNA (0.32) | — | |
| SCHEMBL1966889 | 0.72 | — | — | |
| SCHEMBL29860723 | 0.72 | CYP11B1 (0.31) | — | |
| SCHEMBL2120814 | 0.71 | FFAR3 (0.32) | FFAR3 | |
| SCHEMBL14959573 | 0.70 | BRD4 (0.41) | GRM5PKM | |
| SCHEMBL23542652 | 0.68 | PKM (0.36) | GRM5PKM | |
| SCHEMBL8007382 | 0.67 | CHRM2 (0.36) | — | |
| SCHEMBL25275893 | 0.67 | ITGB3 (0.30) | — | |
| SCHEMBL2225143 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |