Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30394051 | 1.00 | TAAR1 (0.50) | TAAR1IDO1AGXTSIGMAR1CHRM2 | |
| SCHEMBL13460501 | 0.85 | TAAR1 (0.57) | TAAR1IDO1AGXTSIGMAR1CHRM2 | |
| SCHEMBL14570167 | 0.83 | TP53 (0.46) | CHRM2CHRM1CHRM3RAB9ASMN1; SMN2 | |
| SCHEMBL16178937 | 0.82 | DHFR (0.42) | TAAR1SMN1; SMN2GRIN1GRIN2B | |
| SCHEMBL15227173 | 0.82 | GRIN2D (0.46) | GRIN1GRIN2B | |
| SCHEMBL13702623 | 0.81 | ALDH1A1 (0.47) | NPC1SMN1; SMN2MAOB | |
| SCHEMBL9490171 | 0.81 | TAAR1 (0.60) | TAAR1IDO1AGXTSIGMAR1CHRM2 | |
| SCHEMBL13887515 | 0.81 | GRIN2D (0.43) | RAB9ASMN1; SMN2GRIN1GRIN2B | |
| SCHEMBL23922832 | 0.80 | GRIN2B (0.47) | CHRM2CHRM1CHRM3GRIN2B | |
| SCHEMBL31286285 | 0.80 | GRIN2B (0.47) | CHRM2CHRM1CHRM3GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115636817-A | Isatin derivative containing triazole ring and preparation method and application thereof | 山东大学 | 2023-01-24 | — | — | CN | claimed |
| CN-110066273-A | A kind of single arylpyrimidines HIV-1 reverse transcriptase inhibitor of the ring containing triazole and the preparation method and application thereof | 山东大学 | 2019-07-30 | — | — | CN | claimed |
| CN-109705095-A | A kind of condensed ring 1,4-benzoquinone class CDC25 protein phosphatase inhibitor of the ring containing triazole and its preparation method and application | 山东大学 | 2019-05-03 | — | — | CN | claimed |
| CN-108586482-A | A kind of Diarylmiazines HIV-1 inhibitor of the ring containing triazole and its preparation method and application | 山东大学 | 2018-09-28 | — | — | CN | claimed |
| CN-114671874-B | Theophylline acetic acid derivative with anti-tumor activity and preparation method and application thereof | 济南爱思医药科技有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-115636817-B | Isatin derivative containing triazole ring, and preparation method and application thereof | 山东大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-115974847-A | 3- (1,2,3-triazole-4-yl) tetrahydroquinazoline-2,4-diketone derivative and preparation method and application thereof | 中国药科大学 | 2023-04-18 | — | — | CN | disclosed |
| EP-3154964-B1 | TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS | UNIV KANSAS (US) | 2023-04-05 | — | — | EP | disclosed |
| US-11584755-B2 | Dihydrothieno[3,2-b]pyridine compounds | IDEAYA BIOSCIENCES, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| CN-115636817-A | Isatin derivative containing triazole ring and preparation method and application thereof | 山东大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-110540526-B | Carane acidyl 1,2, 3-triazole compound and preparation method and application thereof | 广西大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-114671874-A | Theophylline acetic acid derivative with anti-tumor activity and preparation method and application thereof | 济南爱思医药科技有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-109705095-A | A kind of condensed ring 1,4-benzoquinone class CDC25 protein phosphatase inhibitor of the ring containing triazole and its preparation method and application | 山东大学 | 2019-05-03 | — | — | CN | disclosed |
| WO-2019067442-A1 | DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS | IDEAYA BIOSCIENCES, INC. (US) | 2019-04-04 | — | — | WO | disclosed |
| CN-108586482-A | A kind of Diarylmiazines HIV-1 inhibitor of the ring containing triazole and its preparation method and application | 山东大学 | 2018-09-28 | — | — | CN | disclosed |
| US-9994556-B2 | Triazole modified coumarin and biphenyl amide-based HSP90 inhibitors | UNIVERSITY OF KANSAS (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170253582-A1 | TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS | REATA PHARMACEUTICALS, INC. | 2017-09-07 | — | — | US | disclosed |
| EP-3154964-A1 | TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS | The University of Kansas (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015192099-A1 | TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS | THE UNIVERSITY OF KANSAS (US) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015007613-A1 | O-ALKYL TRIAZOLYL CARBAMATES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2015-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584755-B2 | Dihydrothieno[3,2-b]pyridine compounds | DHFR, CYC1, CYCS | TAAR1 299/4885IDO1 1613/4885AGXT 2452/4885 |
| US-20170253582-A1 | TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS | HSP90AB1, HSP90AB2P, HSP90AA1 | TAAR1 4734/4885IDO1 4496/4885AGXT 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.