Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.54 |
| ▸ | CA1 | P00915 | 11/20 | 0.54 |
| ▸ | CA12 | O43570 | 8/20 | 0.54 |
| ▸ | CA9 | Q16790 | 8/20 | 0.54 |
| ▸ | CA7 | P43166 | 7/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.54 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CFB | P00751 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401122 | 0.86 | RIPK1 (0.46) | CA2CA1CA12CA9CA7 | |
| SCHEMBL16401682 | 0.84 | ROCK2 (0.49) | CA2CA1CA12CA9CA7 | |
| SCHEMBL12478830 | 0.82 | PPID (0.48) | RIPK1HSD11B1 | |
| SCHEMBL16409297 | 0.82 | CA2 (0.51) | CA2CA1CA12CA9CA7 | |
| SCHEMBL216202 | 0.80 | RIPK1 (0.62) | RIPK1HSD11B1 | |
| SCHEMBL27574946 | 0.80 | RIPK1 (0.62) | RIPK1HSD11B1 | |
| SCHEMBL27574934 | 0.80 | RIPK1 (0.62) | RIPK1HSD11B1 | |
| SCHEMBL21962365 | 0.80 | RIPK1 (0.49) | CA2CA1CA12CA9CA7 | |
| SCHEMBL26693398 | 0.79 | PARP14 (0.57) | CPT1ACFBRIPK1HSD11B1 | |
| SCHEMBL29892279 | 0.79 | CCNC (0.51) | RIPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |