Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CFB | P00751 | 1/20 | 0.47 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | CPT1A | P50416 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401485 | 0.84 | CA2 (0.54) | CFBCPT1ACA2CA12CA1 | |
| SCHEMBL17782219 | 0.83 | NR1H2 (0.51) | ROCK2CFBCPT2CPT1ACA2 | |
| SCHEMBL17513435 | 0.83 | ROCK2 (0.53) | ROCK2NR1H2NR1H3RIPK1SIGMAR1 | |
| SCHEMBL28097481 | 0.80 | HSP90AA1 (0.53) | ROCK2PARP14PARP10RIPK1HSP90AA1 | |
| SCHEMBL16401372 | 0.79 | TMEM97 (0.48) | ROCK2CFBCPT2CPT1ACA2 | |
| SCHEMBL216202 | 0.79 | RIPK1 (0.62) | PARP14PARP10RIPK1HSP90AA1HSP90AB1 | |
| SCHEMBL27574934 | 0.79 | RIPK1 (0.62) | PARP14PARP10RIPK1HSP90AA1HSP90AB1 | |
| SCHEMBL27574946 | 0.79 | RIPK1 (0.62) | PARP14PARP10RIPK1HSP90AA1HSP90AB1 | |
| SCHEMBL25319552 | 0.79 | SCD5 (0.47) | ROCK2PARP14PARP10RIPK1HSP90AA1 | |
| SCHEMBL6246105 | 0.79 | RIPK1 (0.66) | PARP14PARP10RIPK1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |