Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 15/20 | 0.59 |
| ▸ | ACHE | P22303 | 5/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230374 | 0.83 | HTR4 (0.61) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL7259567 | 0.80 | HTR4 (0.42) | HTR4ACHECHRM4CHRM5ADRA2C | |
| Hydrochloric Acid SCHEMBL8971273 | 0.79 | HTR4 (0.61) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL7254150 | 0.75 | HTR4 (0.45) | HTR4ACHECHRM4CHRM5ADRA2C | |
| SCHEMBL17709619 | 0.74 | HTR4 (1.00) | HTR4ACHECHRM4CHRM5ADRA2C | |
| SCHEMBL6784774 | 0.70 | DRD2 (0.55) | HTR4ACHECHRM4CHRM5ADRA2C | |
| SCHEMBL4228413 | 0.69 | HTR4 (0.49) | HTR4ACHECHRM4CHRM5ADRA2C | |
| SCHEMBL22022521 | 0.67 | HTR4 (0.68) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL6692234 | 0.67 | HTR4 (0.52) | HTR4ACHEMEN1ALDH1A1KMT2A | |
| SCHEMBL4437515 | 0.67 | HTR4 (0.54) | HTR4ACHEMEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004058-A2 | ACETYLCHOLINESTERASE INHIBITOR COMPOUNDS AND 5HT4 SEROTONERGIC RECEPTOR AGONISTS, WITH PROMNESIA EFFECT, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Université de Caen (FR) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014195593-A2 | ACETYLCHOLINESTERASE INHIBITOR COMPOUNDS AND 5HT4 SEROTONERGIC RECEPTOR AGONISTS, WITH PROMNESIA EFFECT, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | UNIVERSITE DE CAEN (FR) | 2014-12-11 | — | — | WO | disclosed |