Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | MMP12 | P39900 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404105 | 0.94 | POLB (0.61) | POLBHTTGAACYP1A2ALDH1A1 | |
| SCHEMBL14318287 | 0.90 | ATP4A (0.46) | POLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14318364 | 0.85 | LMNA (0.46) | POLBHTTALDH1A1KDM4EMAPT | |
| SCHEMBL14318295 | 0.83 | ALDH1A1 (0.47) | GAAALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL16404110 | 0.81 | ALDH1A1 (0.62) | POLBHTTGAAALDH1A1KDM4E | |
| SCHEMBL14318350 | 0.79 | ATP4A (0.42) | ALDH1A1KDM4E | |
| SCHEMBL14318365 | 0.79 | KDM4E (0.46) | HTTGAAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL16404066 | 0.79 | ALDH1A1 (0.48) | POLBHTTGAAALDH1A1KDM4E | |
| SCHEMBL14684725 | 0.79 | ALDH1A1 (0.54) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL14318382 | 0.78 | RAB9A (0.49) | POLBGAAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |