Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.67 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12078042 | 0.80 | NAMPT (0.77) | KMT2AHTTMAPT | |
| SCHEMBL7410831 | 0.80 | ITGB1 (0.63) | CXCR4GRIN1GRIN2AGRIN2BALDH1A1 | |
| SCHEMBL16404742 | 0.80 | LMNA (0.70) | HDAC6HDAC8HDAC2HDAC3POLB | |
| SCHEMBL4923521 | 0.80 | POLB (0.72) | HDAC6HDAC8HDAC2HDAC3POLB | |
| SCHEMBL20715342 | 0.79 | POLB (0.54) | HDAC6HDAC8HDAC2CXCR4HDAC3 | |
| SCHEMBL22468206 | 0.77 | HDAC6 (1.00) | HDAC6HDAC8HDAC2CXCR4HDAC3 | |
| SCHEMBL17372930 | 0.77 | SMN1; SMN2 (0.68) | POLBKMT2AHTTALDH1A1 | |
| SCHEMBL4916863 | 0.76 | HDAC6 (0.76) | HDAC6HDAC8HDAC2CXCR4HDAC3 | |
| SCHEMBL4927135 | 0.76 | HDAC6 (0.68) | HDAC6HDAC8HDAC2CXCR4HDAC3 | |
| SCHEMBL16404767 | 0.76 | HDAC1 (0.70) | HDAC6HDAC8HDAC2HDAC3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022173-B1 | COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION THEREOF | INSTITUT DE RECH POUR LE DEVELOPPEMENT I R D (FR) | 2019-02-20 | — | — | EP | disclosed |
| US-20190040004-A1 | NEW COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION OF THEREOF | UNIVERSITE DE MONTPELLIER (FR) | 2019-02-07 | — | — | US | disclosed |
| US-20160168084-A1 | NEW COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION OF THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-06-16 | — | — | US | disclosed |
| EP-2826769-A1 | Compounds for the treatment and/or prevention of parasitic diseases and method of production thereof | Institut de Recherche pour le Développement ( IRD) (FR) | 2015-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168084-A1 | NEW COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION OF THEREOF | PIGO, TTPA, TST | HDAC6 334/4885HDAC8 880/4885HDAC2 717/4885 |
| US-20190040004-A1 | NEW COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES AND METHOD OF PRODUCTION OF THEREOF | PIGO, TTPA, TST | HDAC6 334/4885HDAC8 880/4885HDAC2 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.