Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18500853 | 0.95 | APP (0.41) | APPBACE1MEN1KMT2AHRH3 | |
| SCHEMBL16405613 | 0.91 | PKM (0.42) | PKMAPPBACE1MEN1KMT2A | |
| SCHEMBL16405630 | 0.90 | PKM (0.41) | PKMAPPBACE1MEN1KMT2A | |
| SCHEMBL16405615 | 0.88 | RAD52 (0.43) | PKMAPPMEN1KMT2A | |
| SCHEMBL16407044 | 0.88 | ACHE (0.47) | PKMAPPMEN1KMT2A | |
| SCHEMBL18499172 | 0.88 | DRD2 (0.42) | PKMAPPMEN1KMT2A | |
| SCHEMBL18500786 | 0.87 | ACHE (0.42) | PKMAPPMEN1KMT2A | |
| SCHEMBL18499169 | 0.86 | MEN1 (0.40) | APPBACE1MEN1KMT2AHRH3 | |
| SCHEMBL16405606 | 0.86 | HRH3 (0.45) | APPBACE1HRH3NR4A2 | |
| SCHEMBL18499175 | 0.86 | HRH3 (0.44) | APPBACE1HRH3NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150023930-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150023930-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | LRRK2, NLN, AADAT | PKM 2102/4885APP 219/4885BACE1 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.