Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410832 | 0.91 | KDM4E (0.35) | KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16410778 | 0.90 | LMNA (0.38) | LMNAKDM4E | |
| SCHEMBL17757377 | 0.90 | FFAR1 (0.34) | LMNAMAPK14LTA4HEPHX2KDM4E | |
| SCHEMBL17757367 | 0.81 | FFAR1 (0.38) | KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16410622 | 0.80 | KMT2A (0.37) | KDM4EALDH1A1 | |
| SCHEMBL16410818 | 0.80 | MEN1 (0.34) | LMNA | |
| SCHEMBL16410841 | 0.80 | KDM1A (0.32) | LMNA | |
| SCHEMBL17758051 | 0.79 | HIF1A (0.37) | LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL16410739 | 0.79 | KMT2A (0.39) | LMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17757846 | 0.79 | LMNA (0.39) | LMNAKDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |