Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | GNA15 | P30679 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410799 | 0.91 | LMNA (0.32) | KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17757367 | 0.90 | FFAR1 (0.38) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL16410778 | 0.88 | LMNA (0.38) | KDM4E | |
| SCHEMBL16410818 | 0.85 | MEN1 (0.34) | MEN1KMT2AROCK1 | |
| SCHEMBL16410841 | 0.85 | KDM1A (0.32) | — | |
| SCHEMBL17757377 | 0.81 | FFAR1 (0.34) | KDM4EALDH1A1HTTSMN1; SMN2FFAR1 | |
| SCHEMBL17758072 | 0.80 | HIF1A (0.40) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL17757421 | 0.80 | FFAR1 (0.39) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL16410725 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL16410740 | 0.80 | MEN1 (0.35) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |