Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410799 | 0.90 | LMNA (0.32) | LMNAKDM4E | |
| SCHEMBL16410622 | 0.89 | KMT2A (0.37) | KDM4EMAPTNPC1GAAMAPK1 | |
| SCHEMBL16410818 | 0.88 | MEN1 (0.34) | LMNA | |
| SCHEMBL16410841 | 0.88 | KDM1A (0.32) | LMNAMAPK1 | |
| SCHEMBL16410739 | 0.88 | KMT2A (0.39) | LMNAKDM4EMAPTNPC1GAA | |
| SCHEMBL17757846 | 0.88 | LMNA (0.39) | LMNAKDM4EMAPTNPC1GAA | |
| SCHEMBL16410832 | 0.88 | KDM4E (0.35) | KDM4E | |
| SCHEMBL16410721 | 0.86 | SIGMAR1 (0.33) | LMNA | |
| SCHEMBL16410831 | 0.85 | MAPT (0.32) | LMNAKDM4EMAPTGAA | |
| SCHEMBL16410840 | 0.81 | ACAT2 (0.42) | LMNAKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |