Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17758056 | 0.90 | APP (0.35) | KDM1AACAT2ALOX15MAPK1APP | |
| SCHEMBL16410778 | 0.88 | LMNA (0.38) | MAPK1LMNA | |
| SCHEMBL16410818 | 0.88 | MEN1 (0.34) | KDM1AACAT2APPATG4BLMNA | |
| SCHEMBL16410832 | 0.85 | KDM4E (0.35) | — | |
| SCHEMBL16410840 | 0.82 | ACAT2 (0.42) | ACAT2APPLMNA | |
| SCHEMBL16410799 | 0.80 | LMNA (0.32) | LMNA | |
| SCHEMBL16410606 | 0.79 | ACAT2 (0.40) | ACAT2 | |
| SCHEMBL17757255 | 0.79 | MAPK1 (0.37) | KDM1AALOX15MAPK1APP | |
| SCHEMBL16410721 | 0.78 | SIGMAR1 (0.33) | LMNA | |
| SCHEMBL17758049 | 0.78 | ACAT2 (0.43) | ACAT2APPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |