Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | PTPRF | P10586 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16425579 | 0.87 | RAB9A (0.59) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL3811053 | 0.74 | PTPN1 (0.48) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL17719230 | 0.73 | NFKB1 (0.60) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL16425581 | 0.70 | PTPN1 (0.61) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL1067561 | 0.70 | HDAC2 (0.77) | HDAC2HDAC1 | |
| SCHEMBL2274783 | 0.69 | HDAC2 (0.62) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13701152 | 0.69 | RAB9A (0.74) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL2270361 | 0.69 | RAB9A (0.59) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL7003615 | 0.69 | JAK2 (0.63) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL2249007 | 0.69 | IKBKB (0.64) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688653-B2 | Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688653-B2 | Ethoxyphenyl thienyl compounds and methods for the treatment of bacterial infections | DUKE UNIVERSITY (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | UNIV DUKE (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | UNIV DUKE (US) | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031658-A1 | ETHOXYPHENYL THIENYL COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS | GGPS1, FDPS, FNTA | NPC1 816/4885RAB9A 1772/4885NFKB1 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.