Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11144108 | 0.83 | LMNA (0.44) | SMN1; SMN2HPGDMAPTRAB9AKMT2A | |
| SCHEMBL10436311 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDXBP1MAPTPRSS1 | |
| SCHEMBL14625736 | 0.81 | PRSS1 (0.47) | SMN1; SMN2HPGDXBP1MAPTPRSS1 | |
| SCHEMBL4594842 | 0.80 | ELANE (0.56) | SMN1; SMN2HPGDXBP1MAPTPRSS1 | |
| SCHEMBL12286433 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2HPGDMAPTRAB9AKMT2A | |
| SCHEMBL1714626 | 0.78 | LMNA (0.59) | SMN1; SMN2HPGDXBP1MAPTPRSS1 | |
| SCHEMBL10585505 | 0.78 | HTT (0.47) | SMN1; SMN2HPGDXBP1MAPTPRSS1 | |
| SCHEMBL13893604 | 0.77 | KMT2A (0.43) | SMN1; SMN2HPGDMAPTKMT2AMEN1 | |
| SCHEMBL20036375 | 0.77 | TDP1 (0.48) | SMN1; SMN2HPGDMAPTPRSS1RAB9A | |
| Hydrogen Peroxide SCHEMBL9578945 | 0.77 | LMNA (0.57) | SMN1; SMN2HPGDXBP1MAPTPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940896-B2 | Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2015-01-27 | — | — | US | disclosed |