Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007069 | 0.88 | MAPT (0.39) | MAPTNPSR1CYP3A4MAPK1HTT | |
| Bromide SCHEMBL30903858 | 0.85 | MAPT (0.38) | MAPTNPSR1CYP3A4MAPK1HTT | |
| SCHEMBL28239363 | 0.85 | MAPT (0.38) | MAPTNPSR1CYP3A4MAPK1HTT | |
| Hydrochloric Acid SCHEMBL1156365 | 0.85 | SMN1; SMN2 (0.41) | MAPTNPSR1CYP3A4MAPK1HTT | |
| SCHEMBL28424843 | 0.79 | MAPT (0.34) | MAPTNPSR1CYP3A4MAPK1HTT | |
| SCHEMBL28120267 | 0.79 | MAPT (0.34) | MAPTNPSR1NOTUMCYP3A4MAPK1 | |
| SCHEMBL27850842 | 0.78 | KCNH2 (0.42) | MAPTKDM4ESMN1; SMN2PLD1 | |
| SCHEMBL4708569 | 0.78 | CCNC (0.40) | MAPTNPSR1CYP3A4 | |
| SCHEMBL5577143 | 0.76 | FAAH (0.34) | MAPTNPSR1MAPK1HTTALDH1A1 | |
| SCHEMBL28107651 | 0.76 | ALDH1A1 (0.39) | MAPTNPSR1MAPK1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783543-B2 | Aminoimidazopyridazines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-10-10 | — | — | US | disclosed |
| US-9284319-B2 | Heterocyclyl aminoimidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-03-15 | — | — | US | disclosed |
| US-20150291599-A1 | AMINOIMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150038485-A1 | HETEROCYCLYL AMINOIMIDAZOPYRIDAZINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-02-05 | — | — | US | disclosed |
| CN-103497190-A | Derivative of imidazole [4, 5-f] [1, 10] phenanthroline as well as preparation method and application thereof | BOE TECHNOLOGY GROUP CO LTD | 2014-01-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038485-A1 | HETEROCYCLYL AMINOIMIDAZOPYRIDAZINES | CCND2, CCND1, CCNI | MAPT 3271/4885NPSR1 1814/4885NOTUM 3929/4885 |
| US-20150291599-A1 | AMINOIMIDAZOPYRIDAZINES | CCND2, CCND1, CCNI | MAPT 3412/4885NPSR1 1645/4885NOTUM 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.