Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984775 | 0.82 | CCNB2 (0.42) | CYP11B2GCGRMAPK14SCN10AGABRG2 | |
| SCHEMBL18752539 | 0.78 | GRM2 (0.40) | GCGRMAPK14EGLN2 | |
| SCHEMBL27806612 | 0.77 | KIF11 (0.51) | PDE3BPDE3ACYP11B1CYP11B2GCGR | |
| SCHEMBL34471260 | 0.75 | PTGS1 (0.51) | PDE3BPDE3ACYP11B1CYP11B2GCGR | |
| SCHEMBL18752751 | 0.74 | CYP11B2 (0.55) | CYP11B1CYP11B2 | |
| SCHEMBL13860056 | 0.74 | PGR (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL19933113 | 0.72 | GCGR (0.50) | PDE3BPDE3ACYP11B1CYP11B2GCGR | |
| SCHEMBL34472104 | 0.72 | EGLN2 (0.44) | PDE3BPDE3ACYP11B1CYP11B2SCN10A | |
| SCHEMBL17630052 | 0.72 | PDE3B (0.46) | PDE3BPDE3ACYP11B1CYP11B2SCN10A | |
| SCHEMBL28165919 | 0.72 | MMP3 (0.57) | PDE3BPDE3ACYP11B1CYP11B2EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027599-B1 | 1,3-DISUBSTITUTED CYCLOPENTANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015014446-A1 | 1,3-DISUBSTITUTED CYCLOPENTANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | WO | disclosed |