Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17714975 | 0.85 | POLB (0.57) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL10000449 | 0.85 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL10066960 | 0.83 | ALDH1A1 (0.56) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL12156954 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL15046557 | 0.80 | CHRM2 (0.60) | ALDH1A1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL9810842 | 0.79 | ALDH1A1 (0.58) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL8005568 | 0.79 | CASP1 (0.60) | ALDH1A1NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL10779928 | 0.79 | KDM4E (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15046862 | 0.78 | CASP3 (0.53) | ALDH1A1NPC1RAB9ALMNAMAPT | |
| SCHEMBL262252 | 0.77 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952009-B2 | Chroman derivatives as TRPM8 inhibitors | AMGEN INC. (US) | 2015-02-10 | — | — | US | disclosed |