Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | DRD1 | P21728 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | DRD5 | P21918 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.66 |
| ▸ | HTR1D | P28221 | 1/20 | 0.66 |
| ▸ | HTR1B | P28222 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | HTR1E | P28566 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | GPR183 | P32249 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18624119 | 0.90 | DRD2 (0.53) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL19563749 | 0.85 | DRD2 (0.64) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL27959775 | 0.84 | DRD2 (0.64) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL23895117 | 0.83 | HTR1A (0.69) | DRD2HTR1AHTR2A | |
| SCHEMBL1039830 | 0.81 | DRD2 (0.75) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL1037951 | 0.81 | DRD2 (0.64) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL1037909 | 0.81 | DRD2 (0.66) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL19088099 | 0.81 | HTR1A (0.61) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL1035763 | 0.80 | DRD2 (0.70) | DRD2HTR1AHTR2AADRB2ADRB1 | |
| SCHEMBL19549049 | 0.80 | DRD2 (0.62) | DRD2HTR1AHTR2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2017-11-09 | — | — | US | disclosed |
| US-20170145001-A1 | PROCESSES FOR PREPARING BREXPIPRAZOLE | SCINOPHARM TAIWAN, LTD. (TW) | 2017-05-25 | — | — | US | disclosed |
| US-20160272624-A1 | METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-09-22 | — | — | US | disclosed |
| US-20150045356-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CYP4Z1, CYP4X1, CYP4B1 | DRD2 1044/4885HTR1A 251/4885HTR2A 256/4885 |
| US-20160272624-A1 | METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF | CYP3A4, CYP2C19, POR | DRD2 973/4885HTR1A 190/4885HTR2A 140/4885 |
| US-20170145001-A1 | PROCESSES FOR PREPARING BREXPIPRAZOLE | CYP2B6, CYP2C19, CYP3A4 | DRD2 861/4885HTR1A 115/4885HTR2A 83/4885 |
| US-20150045356-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | DRD2 615/4885HTR1A 434/4885HTR2A 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.