Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454802 | 0.89 | MAPT (0.49) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454709 | 0.87 | SMN1; SMN2 (0.59) | MAPTTSHRGAAHSD17B10RAB9A | |
| SCHEMBL16454809 | 0.86 | TSHR (0.53) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454878 | 0.82 | LMNA (0.51) | MAPTGAAMAPK1HSD17B10RAB9A | |
| SCHEMBL16454794 | 0.81 | ALDH1A1 (0.61) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454880 | 0.81 | MAPT (0.55) | MAPTTSHRHSD17B10RAB9AKMT2A | |
| SCHEMBL16454891 | 0.78 | NPSR1 (0.53) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454893 | 0.78 | NPSR1 (0.55) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454892 | 0.77 | NPSR1 (0.52) | MAPTTSHRGAAMAPK1HSD17B10 | |
| SCHEMBL16454723 | 0.76 | AHR (0.58) | MAPTHSD17B10KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015020565-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES EXHIBITING ANTAGONIST PROPERTIES TO ADENOSINE A2A RECEPTORS, AND USE THEREOF | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НЬЮВАК" (ООО "НЬЮВАК") (RU) | 2015-02-12 | — | — | WO | disclosed |