Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454821 | 0.82 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL16454887 | 0.76 | GAA (0.53) | POLBMEN1KMT2AMAPT | |
| SCHEMBL16454822 | 0.72 | HSD11B1 (0.43) | POLBHSD11B1RAB9ANPC1 | |
| SCHEMBL16454895 | 0.71 | HSD11B1 (0.48) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL16454833 | 0.70 | SMN1; SMN2 (0.51) | POLBMEN1KMT2AMAPT | |
| SCHEMBL16454831 | 0.69 | HPGD (0.53) | POLBMEN1KMT2ARAB9ATDP1 | |
| SCHEMBL16454834 | 0.69 | MAPK1 (0.49) | HSD11B1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL16454893 | 0.68 | NPSR1 (0.55) | POLBHSD11B1MEN1KMT2ARAB9A | |
| SCHEMBL16454882 | 0.68 | SMN1; SMN2 (0.54) | MEN1KMT2AMAPT | |
| SCHEMBL16454903 | 0.67 | ALOX15 (0.47) | HSD11B1MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015020565-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES EXHIBITING ANTAGONIST PROPERTIES TO ADENOSINE A2A RECEPTORS, AND USE THEREOF | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НЬЮВАК" (ООО "НЬЮВАК") (RU) | 2015-02-12 | — | — | WO | disclosed |