Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454878 | 0.88 | LMNA (0.51) | HTTALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL16454880 | 0.88 | MAPT (0.55) | IRAK4ATRALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL16454802 | 0.83 | MAPT (0.49) | IRAK4ATRNPC1RAB9AMAPT | |
| SCHEMBL16454785 | 0.80 | ALDH1A1 (0.52) | HTTALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL16454830 | 0.78 | MAPT (0.50) | IRAK4ALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL16454784 | 0.76 | TSHR (0.46) | HTTALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL16454814 | 0.75 | POLB (0.46) | HTTALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL16454723 | 0.74 | AHR (0.58) | IRAK4ATRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12872726 | 0.72 | ITGB1 (0.48) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL22573967 | 0.71 | ATR (0.66) | IRAK4ATRHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015020565-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES EXHIBITING ANTAGONIST PROPERTIES TO ADENOSINE A2A RECEPTORS, AND USE THEREOF | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НЬЮВАК" (ООО "НЬЮВАК") (RU) | 2015-02-12 | — | — | WO | disclosed |