Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455123 | 0.90 | PHGDH (0.40) | ALDH1A1SMN1; SMN2MAPTKMT2ANPC1 | |
| SCHEMBL16455067 | 0.85 | HPGD (0.47) | ALDH1A1SMN1; SMN2TSHRPOLBMAPT | |
| SCHEMBL18848469 | 0.82 | POLB (0.46) | POLBKMT2ANPC1KDM4EHSD17B10 | |
| SCHEMBL16455031 | 0.80 | NPC1 (0.47) | ALDH1A1SMN1; SMN2TSHRMAPTKMT2A | |
| SCHEMBL16455177 | 0.80 | KDM1A (0.44) | ALDH1A1SMN1; SMN2MAPTKMT2ANPC1 | |
| SCHEMBL18848747 | 0.79 | KDM1A (0.46) | ALDH1A1SMN1; SMN2TSHRPOLB | |
| SCHEMBL18848433 | 0.79 | NPC1 (0.46) | ALDH1A1SMN1; SMN2TSHRMAPTKMT2A | |
| SCHEMBL18848758 | 0.76 | KDM1A (0.45) | ALDH1A1POLB | |
| SCHEMBL18848613 | 0.74 | KDM1A (0.46) | ALDH1A1 | |
| SCHEMBL16455199 | 0.72 | KMT2A (0.49) | ALDH1A1SMN1; SMN2TSHRPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015021128-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES INC. (US) | 2015-02-12 | — | — | WO | disclosed |