Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848747 | 0.89 | KDM1A (0.46) | POLBKDM1A | |
| SCHEMBL16455162 | 0.82 | MMP8 (0.40) | POLBKMT2AKDM4EHSD17B10NPC1 | |
| SCHEMBL16455069 | 0.80 | KDM1A (0.51) | KDM1ANPC1 | |
| SCHEMBL18848758 | 0.79 | KDM1A (0.45) | POLBKDM1A | |
| SCHEMBL16455067 | 0.78 | HPGD (0.47) | POLBKMT2AMAPK1KDM4EHSD17B10 | |
| SCHEMBL18848613 | 0.78 | KDM1A (0.46) | KDM1A | |
| SCHEMBL16455031 | 0.75 | NPC1 (0.47) | KMT2ANPC1HDAC1 | |
| SCHEMBL18848433 | 0.74 | NPC1 (0.46) | KMT2ANPC1HDAC1 | |
| SCHEMBL16455072 | 0.74 | KDM1A (0.60) | POLBKMT2AKDM1A | |
| SCHEMBL18848618 | 0.72 | KMT2A (0.51) | POLBKMT2AKDM1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |