Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 15/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455163 | 0.89 | KDM1A (0.53) | KDM1ATGM2PHGDH | |
| SCHEMBL16455166 | 0.88 | KDM1A (0.59) | KDM1ATGM2 | |
| SCHEMBL16455199 | 0.88 | KMT2A (0.49) | TGM2ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL18848468 | 0.88 | CTSB (0.55) | KDM1AMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL18848622 | 0.87 | KMT2A (0.43) | KDM1ATGM2MEN1MAPTKMT2A | |
| SCHEMBL16447253 | 0.86 | KDM1A (0.53) | KDM1A | |
| SCHEMBL18848746 | 0.86 | KDM1A (0.58) | KDM1A | |
| SCHEMBL16447254 | 0.86 | KDM1A (0.53) | KDM1A | |
| SCHEMBL16455202 | 0.85 | KDM1A (0.65) | KDM1A | |
| SCHEMBL18848757 | 0.84 | KDM1A (0.66) | KDM1ATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015021128-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES INC. (US) | 2015-02-12 | — | — | WO | disclosed |