Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261714 | 0.83 | LMNA (0.54) | PORCNABL1SLC2A1CYP3A4CYP1A2 | |
| SCHEMBL16456582 | 0.83 | MAPK14 (0.43) | PORCNCNR1 | |
| SCHEMBL16456595 | 0.81 | MAPK14 (0.37) | PORCNCYP3A4MEN1KMT2APIK3CG | |
| SCHEMBL16456528 | 0.81 | ABL1 (0.42) | PORCNABL1 | |
| SCHEMBL4767825 | 0.73 | ABL1 (0.53) | PORCNABL1SLC2A1MKNK1MKNK2 | |
| SCHEMBL2787427 | 0.72 | STIM1 (0.48) | ABL1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4768204 | 0.72 | IL2 (0.60) | ABL1SLC2A1DYRK1A | |
| SCHEMBL14562873 | 0.71 | IL2 (0.42) | PORCNABL1MKNK2PIK3CG | |
| SCHEMBL2785171 | 0.71 | CYP3A4 (0.41) | MKNK2KDRCYP3A4CYP1A2MEN1 | |
| SCHEMBL15463139 | 0.71 | ABL1 (0.48) | PORCNABL1SLC2A1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846372-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2014-04-16 | — | — | EP | claimed |