Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17435133 | 0.84 | IL2 (0.40) | IL2PIK3CDPIK3CBPIK3CGPORCN | |
| SCHEMBL8263238 | 0.83 | LMNA (0.51) | MAPK14POLBKMT2AMEN1GAA | |
| SCHEMBL16456528 | 0.81 | ABL1 (0.42) | MAPK14PORCN | |
| SCHEMBL16456523 | 0.81 | PORCN (0.52) | KMT2AMEN1PIK3CGPORCNCYP3A4 | |
| SCHEMBL16456582 | 0.81 | MAPK14 (0.43) | MAPK14POLBMAPTPORCN | |
| SCHEMBL17435130 | 0.77 | STIM1 (0.36) | KMT2AIL2PORCNCYP3A4AAK1 | |
| SCHEMBL16456511 | 0.74 | IMPDH2 (0.44) | AAK1 | |
| SCHEMBL450074 | 0.73 | IL2 (0.42) | POLBIL2PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2785171 | 0.73 | CYP3A4 (0.41) | POLBKMT2AIL2MEN1MAPT | |
| SCHEMBL2787427 | 0.72 | STIM1 (0.48) | POLBKMT2AMEN1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846372-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2014-04-16 | — | — | EP | claimed |