Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KCNB1 | Q14721 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17435143 | 0.84 | IL2 (0.39) | ABL1PTGDR2MAPK14SMOPORCN | |
| SCHEMBL8261109 | 0.83 | LMNA (0.51) | ABL1PTGDR2MAPK14SMOPORCN | |
| SCHEMBL16456582 | 0.83 | MAPK14 (0.43) | MAPK14SMOPORCNCHEK2 | |
| SCHEMBL5033811 | 0.82 | ABL1 (0.43) | ABL1PTGDR2MAPK14SMOPORCN | |
| SCHEMBL16456523 | 0.81 | PORCN (0.52) | ABL1PORCN | |
| SCHEMBL16456595 | 0.81 | MAPK14 (0.37) | MAPK14PORCN | |
| SCHEMBL14562850 | 0.80 | PORCN (0.37) | ABL1PTGDR2MAPK14SMOPORCN | |
| SCHEMBL5030737 | 0.76 | ADORA2A (0.51) | ABL1PTGDR2KCNB1MAPK14SMO | |
| SCHEMBL5030575 | 0.76 | KCNB1 (0.52) | ABL1PTGDR2KCNB1PORCNNTRK1 | |
| SCHEMBL5033015 | 0.75 | ABL1 (0.47) | ABL1PTGDR2MAPK14SMOPORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846372-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2014-04-16 | — | — | EP | claimed |