Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260401 | 0.83 | LMNA (0.57) | MAPK14TRPV1LMNAKDM4EALDH1A1 | |
| SCHEMBL16456528 | 0.83 | ABL1 (0.42) | MAPK14PORCNSMOCHEK2 | |
| SCHEMBL16456523 | 0.83 | PORCN (0.52) | PORCNCNR1 | |
| SCHEMBL16456595 | 0.81 | MAPK14 (0.37) | MAPK14PORCNPOLBMAPT | |
| SCHEMBL2787427 | 0.72 | STIM1 (0.48) | KDM4EALDH1A1POLBMAPTHPGD | |
| SCHEMBL2784228 | 0.72 | KDM4E (0.42) | PORCNLMNAKDM4EALDH1A1POLB | |
| SCHEMBL4764906 | 0.72 | IL2 (0.60) | MAPK14TRPV1 | |
| SCHEMBL14562873 | 0.71 | IL2 (0.42) | MAPK14PORCN | |
| SCHEMBL15463135 | 0.71 | MAPK14 (0.49) | MAPK14TRPV1CNR1SMOGRM4 | |
| SCHEMBL2785129 | 0.71 | MAPT (0.41) | ALDH1A1POLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846372-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2014-04-16 | — | — | EP | claimed |