Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15556408 | 0.88 | LMNA (0.33) | ALDH1A1LMNARECQL | |
| SCHEMBL17363936 | 0.84 | MAPT (0.32) | LMNAADORA2AADORA1MAPTKMT2A | |
| SCHEMBL15555065 | 0.84 | ADORA2A (0.39) | ALDH1A1ADORA2AADORA1MAPTMEN1 | |
| SCHEMBL15556257 | 0.82 | NOTUM (0.35) | ALDH1A1LMNAPOLBMAPTMEN1 | |
| SCHEMBL7092394 | 0.82 | NPC1 (0.47) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL15557472 | 0.81 | DHFR (0.31) | ALDH1A1LMNAPOLBMAPTMEN1 | |
| SCHEMBL17393915 | 0.80 | ALDH1A1 (0.40) | ALDH1A1LMNATP53CYP3A4NPSR1 | |
| SCHEMBL15969244 | 0.80 | LMNA (0.39) | ALDH1A1LMNACYP3A4NPSR1MAPT | |
| SCHEMBL15555571 | 0.79 | KDM4E (0.30) | ALDH1A1LMNAPOLBMAPTMEN1 | |
| SCHEMBL16458325 | 0.79 | POLB (0.33) | ALDH1A1LMNAPOLBADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104428289-B | As the triazole compounds of antivirotic | 弗·哈夫曼-拉罗切有限公司 | 2017-06-23 | — | — | CN | claimed |
| EP-2870143-B1 | TRIAZOLE COMPOUNDS AS ANTIVIRALS | HOFFMANN LA ROCHE (CH) | 2017-05-17 | — | — | EP | claimed |
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | claimed |
| CN-104428289-A | Triazole compounds as antivirals | HOFFMANN LA ROCHE | 2015-03-18 | — | — | CN | claimed |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2014-01-09 | — | — | US | claimed |
| CN-104428289-B | As the triazole compounds of antivirotic | 弗·哈夫曼-拉罗切有限公司 | 2017-06-23 | — | — | CN | disclosed |
| EP-2870143-B1 | TRIAZOLE COMPOUNDS AS ANTIVIRALS | HOFFMANN LA ROCHE (CH) | 2017-05-17 | — | — | EP | disclosed |
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| CN-104428289-A | Triazole compounds as antivirals | HOFFMANN LA ROCHE | 2015-03-18 | — | — | CN | disclosed |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2014-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307461-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | ALDH1A1 222/4885LMNA 3929/4885TP53 2824/4885 |
| US-20140010783-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | ALDH1A1 222/4885LMNA 3929/4885TP53 2824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.