Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10382407 | 0.66 | GBA1 (0.55) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL6235486 | 0.66 | DNTT (0.36) | ALDH1A1HPGDKDM4E | |
| SCHEMBL221917 | 0.65 | GBA1 (0.41) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL587248 | 0.65 | HLCS (0.37) | GAAALDH1A1HPGDABL1RIN1 | |
| SCHEMBL3636070 | 0.63 | MEN1 (0.43) | GBA1TP53GAAALDH1A1ABL1 | |
| SCHEMBL3806103 | 0.62 | GBA1 (0.46) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL169504 | 0.62 | ABL1 (0.41) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL8520114 | 0.62 | GBA1 (0.39) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL11777551 | 0.62 | GBA1 (0.46) | GBA1MGLLPTGS1PTGS2TP53 | |
| SCHEMBL251394 | 0.61 | PTGS1 (0.36) | GBA1MGLLPTGS1PTGS2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482231-B | Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof | BAYER IP GMBH | 2014-12-17 | — | — | CN | disclosed |
| US-8691817-B2 | Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-08 | — | — | US | disclosed |
| CN-102482231-A | Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof | Bayer Pharma AG | 2012-05-30 | — | — | CN | disclosed |