Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | DNTT | P04053 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.30 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16324744 | 0.74 | DNTT (0.36) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5175876 | 0.73 | DNTT (0.39) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7464658 | 0.71 | — | — | |
| SCHEMBL9647065 | 0.69 | DNTT (0.36) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL6235486 | 0.69 | DNTT (0.36) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL251394 | 0.68 | PTGS1 (0.36) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL16465474 | 0.65 | GBA1 (0.38) | ALDH1A1KDM4EHPGDABL1RIN1 | |
| SCHEMBL16229054 | 0.64 | GPR84 (0.35) | HLCSALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5452034 | 0.63 | — | — | |
| SCHEMBL3911611 | 0.63 | ALDH1A1 (0.62) | HLCSALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808241-B | 4-aryl 3, 4-dihydropyrimidine (sulfur) ketone polymer and preparation and application thereof | 清华大学 | 2021-06-01 | — | — | CN | claimed |
| CN-111808241-A | 4-aryl 3, 4-dihydropyrimidine (sulfur) ketone polymer and preparation and application thereof | 清华大学 | 2020-10-23 | — | — | CN | claimed |
| CN-111808241-B | 4-aryl 3, 4-dihydropyrimidine (sulfur) ketone polymer and preparation and application thereof | 清华大学 | 2021-06-01 | — | — | CN | disclosed |
| CN-111808241-A | 4-aryl 3, 4-dihydropyrimidine (sulfur) ketone polymer and preparation and application thereof | 清华大学 | 2020-10-23 | — | — | CN | disclosed |
| US-9174997-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | PH PHARMA CO., LTD. (KR) | 2015-02-12 | — | — | US | disclosed |
| US-8889700-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20140045802-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-13 | — | — | US | disclosed |
| US-8580800-B2 | 1,4-diaryl-pyrimidopyridazine-2,5-diones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-8288402-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-19 | — | — | US | disclosed |
| WO-2010115548-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTITUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-10-14 | — | — | WO | disclosed |
| EP-1807402-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006048308-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2006-05-11 | — | — | WO | disclosed |
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |
| EP-0882026-A4 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | MERCK & CO INC (US) | 1999-04-07 | — | — | EP | disclosed |
| CN-1204325-A | Process for making dihydropyrimidinones | MERCK & CO INC (US) | 1999-01-06 | — | — | CN | disclosed |
| EP-0882026-A1 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | Merck & Co., Inc. (a New Jersey corp.) (US) | 1998-12-09 | — | — | EP | disclosed |
| US-5786472-A | CATALYTIC CONDENSATION OF UREA WITH DIKETONES USIN BORON REAGENT AND ACID CATALYST | MERCK & CO., INC. (US) | 1998-07-28 | — | — | US | disclosed |
| WO-1997021687-A1 | PROCESS FOR MAKING DIHYDROPYRIMIDINONES | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045802-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | TNNI3, TNNT2, PC | HLCS 78/4885ALDH1A1 616/4885L3MBTL1 3575/4885 |
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | STS, SQOR, TST | HLCS 655/4885ALDH1A1 669/4885L3MBTL1 3864/4885 |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | TNNI3, TNNT2, PC | HLCS 79/4885ALDH1A1 552/4885L3MBTL1 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.