Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | POLM | Q9NP87 | 2/20 | 0.41 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.41 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.41 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11358917 | 0.83 | MTNR1A (0.59) | KMT2AKDM4EMEN1RECQLLMNA | |
| SCHEMBL9312497 | 0.79 | KMT2A (0.59) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL22141048 | 0.78 | KMT2A (0.50) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL7559262 | 0.76 | LMNA (0.43) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL16466810 | 0.75 | MTNR1A (0.40) | KMT2AKDM4EMEN1MTNR1AALDH1A1 | |
| SCHEMBL5316653 | 0.75 | IAPP (0.50) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL15548829 | 0.74 | KMT2A (0.54) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL28834444 | 0.73 | KDM4E (0.46) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL27942332 | 0.73 | MEN1 (0.50) | KMT2AKDM4EMEN1RECQLALOX15 | |
| SCHEMBL29373398 | 0.73 | ALDH1A1 (0.58) | KMT2AKDM4EMEN1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2837630-B1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | ASYMCHEM LAB TIANJIN CO LTD (CN) | 2016-11-23 | — | — | EP | disclosed |
| US-9365573-B2 | Method for synthesizing sapropterin dihydrochloride | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2016-06-14 | — | — | US | disclosed |
| US-20150105555-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD (CN) | 2015-04-16 | — | — | US | disclosed |
| EP-2837630-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | Asymchem Laboratories (Tianjin) Co., Ltd (CN) | 2015-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105555-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | CYP51A1, DHCR7, LSS | KMT2A 4271/4885KDM4E 4409/4885MEN1 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.