Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.49 |
| ▸ | CTSK | P43235 | 6/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19235542 | 1.00 | CTSS (0.49) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL9957413 | 0.90 | CTSS (0.49) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL9957411 | 0.90 | CTSS (0.49) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL10143850 | 0.90 | CTSS (0.53) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL6675710 | 0.90 | CTSS (0.53) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL31321421 | 0.90 | CTSS (0.53) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL16459373 | 0.89 | PPARA (0.51) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL16459371 | 0.89 | PPARA (0.51) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL16470394 | 0.89 | CTSS (0.62) | CTSSCTSKKLK5CTSBCTSL | |
| SCHEMBL3498608 | 0.88 | KLK5 (0.60) | CTSSCTSKKLK5CTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017135472-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | ＥＡファーマ株式会社 | 2017-08-10 | — | — | WO | disclosed |
| US-9533985-B2 | Sulfonamide derivative and medicinal use thereof | EA PHARMA CO., LTD. (JP) | 2017-01-03 | — | — | US | disclosed |
| EP-2842945-B1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | EA PHARMA CO LTD (JP) | 2016-10-26 | — | — | EP | disclosed |
| EP-2842945-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | AJINOMOTO CO., INC. (JP) | 2015-03-04 | — | — | EP | disclosed |
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | AJINOMOTO CO., LTD. (JP) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | ITGB4, ITGA4, ITGA2 | CTSS 1999/4885CTSK 3803/4885KLK5 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.